ATC 0175 hydrochloride( —— )

Catalog No. M33831 CAS No. 510733-97-8

ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	109	Get Quote
5MG	155	Get Quote
10MG	250	Get Quote
25MG	495	Get Quote
50MG	840	Get Quote
100MG	1341	Get Quote
500MG	2691	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

ATC 0175 hydrochloride
Note

Research use only, not for human use.
Brief Description

ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective.
Description

ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.
In Vitro

ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively.
In Vivo

ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential.
Synonyms

——
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor | GPR | Melanin-concentrating Hormone Receptor (MCHR)
Research Area

——
Indication

——

Chemical Information

CAS Number

510733-97-8
Formula Weight

461.93
Molecular Formula

C23H26ClF2N5O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 12.5 mg/mL (27.06 mM; Ultrasonic (<60°C)
SMILES

N(C)(C)C=1C2=C(N=C(N[C@H]3CC[C@@H](NC(=O)C4=CC(F)=C(F)C=C4)CC3)N1)C=CC=C2.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks